Leuven I
Intensive Insulin Therapy in Critically Ill Surgical Patients
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 1,548 surgical ICU patients, intensive insulin (80–110 mg/dL) reduced ICU mortality versus conventional control.
N
1548
Disegno
Single-centre RCT, Belgium
Esito
ICU mortality
Rilevanza
3
Risultato4.6% vs 8.0% (p<0.04).
Van den Berghe G, et al. N Engl J Med. 2001;345(19):1359-1367. 10.1056/NEJMoa011300
Discussione e critica
Single-centre, mostly cardiac surgery; NICE-SUGAR later overturned tight control in general ICU.