Leuven I
Intensive Insulin Therapy in Critically Ill Surgical Patients
Patient / Population Intervention / Exposure Comparison Outcome
In 1,548 surgical ICU patients, intensive insulin (80–110 mg/dL) reduced ICU mortality versus conventional control.
N
1,548
Design
Single-centre RCT, Belgium
Endpoint
ICU mortality
Relevance
3
Result4.6% vs 8.0% (p<0.04).
Van den Berghe G, et al. N Engl J Med. 2001;345(19):1359-1367. 10.1056/NEJMoa011300
Discussion & critique
Single-centre, mostly cardiac surgery; NICE-SUGAR later overturned tight control in general ICU.