IDEAL
Initiating Dialysis Early and Late
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 828 patients with stage 5 chronic kidney disease, starting dialysis early did not improve survival compared with a later, symptom-guided start.
N
828
Disegno
Multicentre RCT, median 3.59-year follow-up
Esito
All-cause mortality
Rilevanza
2
Risultato37.6% vs 36.6%; HR 1.04 (95% CI 0.83–1.30; p=0.75).
Cooper BA, et al. N Engl J Med. 2010;363(7):609-619. 10.1056/NEJMoa1000552
Discussione e critica
Shifted practice to symptom-guided rather than eGFR-threshold dialysis initiation.