HYVET
Hypertension in the Very Elderly Trial
Doente / População Intervenção / Exposição Comparação Desfecho
In 3,845 patients with hypertension aged 80 or older, antihypertensive treatment reduced stroke and all-cause mortality compared with placebo.
N
3845
Desenho
Double-blind RCT, stopped early
Desfecho
Fatal or non-fatal stroke
Relevância
2
ResultadoStroke down 30 %; all-cause mortality down 21 %; heart failure down 64 %.
Beckett NS, et al. N Engl J Med. 2008;358(18):1887-1898. 10.1056/NEJMoa0801369
Discussão e crítica
Showed treating hypertension benefits the very elderly — but enrolled relatively fit octogenarians, so frail patients are under-represented.