HYVET

Hypertension in the Very Elderly Trial

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 3,845 patients with hypertension aged 80 or older, antihypertensive treatment reduced stroke and all-cause mortality compared with placebo.

3845

Disegno

Double-blind RCT, stopped early

Esito

Fatal or non-fatal stroke

Rilevanza

RisultatoStroke down 30 %; all-cause mortality down 21 %; heart failure down 64 %.

Beckett NS, et al. N Engl J Med. 2008;358(18):1887-1898. 10.1056/NEJMoa0801369

Discussione e critica

Showed treating hypertension benefits the very elderly — but enrolled relatively fit octogenarians, so frail patients are under-represented.