HALT-IT
Tranexamic Acid in Gastrointestinal Bleeding
Patient / Population Intervention / Exposure Comparison Outcome
In 12,009 patients with acute GI bleeding, tranexamic acid did not reduce death from bleeding versus placebo, and increased venous thromboembolism.
N
12,009
Design
International RCT
Endpoint
Death from bleeding within 5 days
Relevance
2
ResultNo mortality benefit; more VTE with TXA.
HALT-IT Trial Collaborators. Lancet. 2020;395(10241):1927-1936. 10.1016/S0140-6736(20)30848-5
Discussion & critique
Don't use TXA in GI bleeding; the trauma signal does not transfer.