FAME
Fractional Flow Reserve versus Angiography for Multivessel Evaluation
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 1,005 patients with multivessel CAD, FFR-guided PCI reduced MACE at one year versus angiography-guided PCI.
N
1005
Disegno
RCT, 1 yr
Esito
Death, MI, repeat revascularisation
Rilevanza
2
Risultato13.2 % vs 18.3 % (p=0.02). Fewer stents per patient with FFR.
Tonino PAL, et al. N Engl J Med. 2009;360(3):213-224. 10.1056/NEJMoa0807611
Discussione e critica
Embedded FFR (≤ 0.80) into routine PCI. Later FAME-2 added a medical-therapy comparator; ISCHEMIA reopened the question.