EXTEND-IA TNK
Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 202 patients with LVO before thrombectomy within 4.5 h, tenecteplase 0.25 mg/kg improved pre-thrombectomy reperfusion versus alteplase 0.9 mg/kg.
N
202
Disegno
Multicentre open-label RCT, ANZ
Esito
Substantial reperfusion before thrombectomy
Rilevanza
2
Risultato22% vs 10% (Δ 12%; 95% CI 2–21; p=0.03 for superiority). mRS shift OR 1.7.
Campbell BCV, et al. N Engl J Med. 2018;378(17):1573-1582. 10.1056/NEJMoa1716405
Discussione e critica
Tenecteplase is increasingly preferred — single bolus, faster door-to-needle.