Evolut Low Risk

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 1,468 patients with severe AS at low surgical risk, TAVR with a self-expanding valve was non-inferior to surgical aortic-valve replacement for death or disabling stroke at 2 years.

1468

Disegno

RCT, non-inferiority

Esito

Death or disabling stroke at 24 months

Rilevanza

Risultato5.3 % vs 6.7 % (non-inferior); benefit persists at 4 years.

Popma JJ, et al. N Engl J Med. 2019;380(18):1706-1715. 10.1056/NEJMoa1816885

Discussione e critica

With PARTNER 3, extended TAVR to low-risk patients. Self-expanding valves bring more pacemakers; long-term durability data are still maturing.