ESETT
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus
Paciente / Población Intervención / Exposición Comparación Desenlace
In 478 patients with benzodiazepine-refractory status epilepticus, levetiracetam was equivalent on seizure cessation and alertness at 60 min to fosphenytoin or valproate.
N
384
Diseño
Response-adaptive Bayesian RCT, US
Desenlace
Seizure cessation with improved consciousness at 60 min
Relevancia
2
Resultado47% (LEV) vs 45% (FOS) vs 46% (VAL); no significant differences.
Kapur J, et al. N Engl J Med. 2019;381(22):2103-2113. 10.1056/NEJMoa1905795
Discusión y crítica
Three equivalent second-line options — choose by availability, interactions and patient profile.