ELAIN
Early versus Late Initiation of Renal Replacement Therapy in AKI
Doente / População Intervenção / Exposição Comparação Desfecho
In 231 critically ill patients with acute kidney injury, early renal-replacement therapy reduced 90-day mortality compared with delayed initiation.
N
231
Desenho
Single-centre RCT
Desfecho
90-day all-cause mortality
Relevância
3
Resultado39.3% vs 54.7%; HR 0.66 (95% CI 0.45–0.97; p=0.03).
Zarbock A, et al. JAMA. 2016;315(20):2190-2199. 10.1001/jama.2016.5828
Discussão e crítica
Positive but single-centre with a fragility index of 3; contradicted by larger multicentre trials.