ELAIN

Early versus Late Initiation of Renal Replacement Therapy in AKI

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 231 critically ill patients with acute kidney injury, early renal-replacement therapy reduced 90-day mortality compared with delayed initiation.

231

Disegno

Single-centre RCT

Esito

90-day all-cause mortality

Rilevanza

Risultato39.3% vs 54.7%; HR 0.66 (95% CI 0.45–0.97; p=0.03).

Zarbock A, et al. JAMA. 2016;315(20):2190-2199. 10.1001/jama.2016.5828

Discussione e critica

Positive but single-centre with a fragility index of 3; contradicted by larger multicentre trials.