ECASS III
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 821 patients with acute ischaemic stroke 3–4.5 h from onset, alteplase improved mRS 0–1 at 90 days versus placebo.
N
821
Schéma
Double-blind RCT
Critère
mRS 0–1 at 90 days
Pertinence
1
Résultat52.4% vs 45.2% (OR 1.34; 95% CI 1.02–1.76; p=0.04). Symptomatic ICH 2.4% vs 0.2%.
Hacke W, et al. N Engl J Med. 2008;359(13):1317-1329. 10.1056/NEJMoa0804656
Discussion et critique
Extended the thrombolysis window to 4.5 h — now standard.