EARLY TAVR
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis
Patient / Population Intervention / Exposure Comparison Outcome
In 901 patients with asymptomatic severe aortic stenosis, early TAVR reduced death, stroke or unplanned cardiovascular hospitalisation compared with clinical surveillance.
N
901
Design
RCT, open-label
Endpoint
Death, stroke or unplanned CV hospitalisation
Relevance
2
Result26.8 % vs 45.3 % (HR 0.50).
Généreux P, et al. N Engl J Med. 2025;392(3):217-227. 10.1056/NEJMoa2405880
Discussion & critique
No mortality or stroke benefit — the composite is driven by 'soft' hospitalisations, with ~ 70 % crossover from surveillance. Contrasts with the neutral EVOLVED trial.