DEFUSE 3
Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 182 patients with anterior-circulation LVO 6–16 h, small core and perfusion mismatch, thrombectomy improved functional outcome at 90 days versus medical management.
N
182
Disegno
Multicentre RCT; stopped early for efficacy
Esito
mRS shift / mRS 0–2 at 90 days
Rilevanza
1
RisultatoOR 2.77 (95% CI 1.63–4.70; p<0.001); mRS 0–2 45% vs 17% (RR 2.67). NNT ≈ 4 for functional independence.
Albers GW, et al. N Engl J Med. 2018;378(8):708-718. 10.1056/NEJMoa1713973
Discussione e critica
With DAWN defines the 6–24 h window using perfusion-imaging mismatch selection.