DEFUSE 3
Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
Paciente / Población Intervención / Exposición Comparación Desenlace
In 182 patients with anterior-circulation LVO 6–16 h, small core and perfusion mismatch, thrombectomy improved functional outcome at 90 days versus medical management.
N
182
Diseño
Multicentre RCT; stopped early for efficacy
Desenlace
mRS shift / mRS 0–2 at 90 days
Relevancia
1
ResultadoOR 2.77 (95% CI 1.63–4.70; p<0.001); mRS 0–2 45% vs 17% (RR 2.67). NNT ≈ 4 for functional independence.
Albers GW, et al. N Engl J Med. 2018;378(8):708-718. 10.1056/NEJMoa1713973
Discusión y crítica
With DAWN defines the 6–24 h window using perfusion-imaging mismatch selection.