DAWN
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
Doente / População Intervenção / Exposição Comparação Desfecho
In 206 patients with LVO stroke 6–24 h from last known well, thrombectomy + standard care improved functional independence at 90 days versus standard care.
N
206
Desenho
Multicentre RCT; stopped early for efficacy
Desfecho
Utility-weighted mRS / mRS 0–2 at 90 days
Relevância
1
ResultadomRS 0–2: 49% vs 13% (adj. Δ 33%; 95% CI 21–44). Per supplement, NNT ≈ 2.8 for functional independence.
Nogueira RG, et al. N Engl J Med. 2018;378(1):11-21. 10.1056/NEJMoa1706442
Discussão e crítica
Extended the EVT window to 24 h using clinical–core mismatch.