Cuijpers Placebo
Psychotherapy vs Pill Placebo for Depression
Paciente / Población Intervención / Exposición Comparación Desenlace
Across 10 trials and 1,240 adults with depression, structured psychotherapy produced a small additional benefit over pill placebo.
N
1240
Diseño
Meta-analysis
Desenlace
Standardised mean difference in depression severity
Relevancia
3
Resultadog=0.25; NNT 7.1 — similar in magnitude to the antidepressant–placebo difference.
Cuijpers P, et al. Psychol Med. 2014;44(4):685-695. 10.1017/S0033291713000457
Discusión y crítica
Recalibrates expectations: against the most rigorous control, the specific psychotherapy effect is modest.