Cuijpers Placebo
Psychotherapy vs Pill Placebo for Depression
Patient / Population Intervention / Exposition Vergleich Endpunkt
Across 10 trials and 1,240 adults with depression, structured psychotherapy produced a small additional benefit over pill placebo.
N
1.240
Design
Meta-analysis
Endpunkt
Standardised mean difference in depression severity
Relevanz
3
Ergebnisg=0.25; NNT 7.1 — similar in magnitude to the antidepressant–placebo difference.
Cuijpers P, et al. Psychol Med. 2014;44(4):685-695. 10.1017/S0033291713000457
Diskussion & Kritik
Recalibrates expectations: against the most rigorous control, the specific psychotherapy effect is modest.