Cuijpers 2023

Mega-Meta-Analysis of CBT for Adult Depression

Paziente / Popolazione Intervento / Esposizione Confronto Esito

Across 409 trials and 52,702 adults with depression, cognitive behavioural therapy produced moderate-to-large effects acutely and a durable edge long-term relative to waitlist, care-as-usual, pill placebo or antidepressants.

52.702

Disegno

Systematic review and meta-analysis

Esito

Standardised mean difference in depression severity

Rilevanza

Risultatovs control conditions (waitlist/care-as-usual pooled) g=0.79 (95% CI 0.70-0.89, NNT 3.8); vs other psychotherapies g=0.06 (0-0.12); vs pharmacotherapies no acute difference g=0.08 (-0.07 to 0.24), CBT superior at 6-12mo follow-up g=0.34 (0.09-0.58)

Cuijpers P, et al. World Psychiatry. 2023;22(1):105-115. 10.1002/wps.21069

Discussione e critica

Largest synthesis to date — anchors CBT as first-line and quantifies how control type inflates the apparent effect.