CREATE
Cardiovascular Risk Reduction by Early Anemia Treatment with Epoetin Beta
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 603 patients with CKD and anaemia, complete correction of haemoglobin did not reduce cardiovascular events compared with partial correction.
N
603
Disegno
RCT
Esito
Cardiovascular composite
Rilevanza
3
RisultatoHR 0.78 (95% CI 0.53–1.14; p=0.20); earlier dialysis with the higher target.
Drüeke TB, et al. N Engl J Med. 2006;355(20):2071-2084. 10.1056/NEJMoa062276
Discussione e critica
Companion to CHOIR; no benefit from normalising haemoglobin.