CONVINCE

Comparison of High-Dose Haemodiafiltration with High-Flux Haemodialysis

Patient / Population Intervention / Exposure Comparison Outcome

In 1,360 prevalent haemodialysis patients, high-dose haemodiafiltration reduced all-cause mortality compared with conventional high-flux haemodialysis.

1,360

Design

International open-label RCT, median 30-month follow-up

Endpoint

All-cause mortality

Relevance

Result17.3% vs 21.9%; HR 0.77 (95% CI 0.65–0.93).

Blankestijn PJ, et al. N Engl J Med. 2023;389(8):700-709. 10.1056/NEJMoa2304820

Discussion & critique

First clearly positive haemodiafiltration mortality trial; a relatively healthy European cohort limits generalisability.