COMBINE
Combined Pharmacotherapies and Behavioural Interventions
Patient / Population Intervention / Exposure Comparison Outcome
In 1,383 adults with alcohol dependence, medical management plus naltrexone or combined behavioural intervention reduced heavy-drinking days relative to placebo or acamprosate, with no additive effect.
N
1,383
Design
9-arm RCT, USA
Endpoint
Percent days abstinent and time to heavy-drinking relapse
Relevance
1
ResultNaltrexone (HR 0.72) and CBI each effective with medical management; acamprosate no effect; no additive benefit.
Anton RF, et al. JAMA. 2006;295(17):2003-2017. 10.1001/jama.295.17.2003
Discussion & critique
Established a flexible pharma + behavioural toolkit; the long-debated acamprosate signal failed in this US sample.