COAPT
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy
Paciente / Población Intervención / Exposición Comparación Desenlace
In 614 patients with HF and severe secondary mitral regurgitation, MitraClip plus GDMT reduced HF hospitalisation and all-cause mortality compared with GDMT alone.
N
614
Diseño
RCT, 2 yr
Desenlace
HF hospitalisation rate
Relevancia
1
Resultado35.8 vs 67.9 per 100 pt-yr (HR 0.53). Mortality 29.1 % vs 46.1 %.
Stone GW, et al. N Engl J Med. 2018;379(24):2307-2318. 10.1056/NEJMoa1806640
Discusión y crítica
MITRA-FR (same year, French) was negative — patient selection (disproportionate MR vs LV dilation) explains the divergence. Identifying COAPT-like anatomy is the practical takeaway.