CMR GUIDE
Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 353 patients with LVEF 36–50 % and scar on cardiac MRI, a primary-prevention ICD was compared with an implantable loop recorder on sudden cardiac death or haemodynamically significant ventricular arrhythmia.
N
353
Schéma
Prospective, multicentre, open-label RCT, 1:1 (ICD vs implantable loop recorder), web-based randomisation stratified by site after core-lab LGE-CMR confirmation; recruitment mid-2015 to mid-2022, follow-up at least 3 years; Australia, UK and Europe
Critère
Time to composite of sudden cardiac death or haemodynamically significant ventricular arrhythmia (ventricular arrhythmia producing syncope or hypotension, SBP <90 mmHg)