CHOIR
Correction of Hemoglobin and Outcomes in Renal Insufficiency
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 1,432 patients with CKD and anaemia, targeting a higher haemoglobin with epoetin increased cardiovascular events compared with a lower haemoglobin target.
N
1432
Disegno
RCT, stopped early
Esito
Composite of death, MI, HF hospitalisation or stroke
Rilevanza
2
RisultatoHR 1.34 (95% CI 1.03–1.74; p=0.03) for the higher target.
Singh AK, et al. N Engl J Med. 2006;355(20):2085-2098. 10.1056/NEJMoa065485
Discussione e critica
Showed that fully normalising haemoglobin is harmful; reframed anaemia targets in CKD.