CHEST
Crystalloid versus Hydroxyethyl Starch Trial
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 7,000 ICU patients, 6% HES 130/0.4 did not reduce 90-day mortality versus saline, but increased renal-replacement therapy.
N
7000
Disegno
Multicentre RCT, ANZ
Esito
90-day all-cause mortality
Rilevanza
1
Risultato18.0% vs 17.0% (NS); RRT 7.0% vs 5.8% (p=0.04).
Myburgh JA, et al. N Engl J Med. 2012;367(20):1901-1911. 10.1056/NEJMoa1209759
Discussione e critica
With 6S and VISEP, retired HES from ICU resuscitation worldwide.