CATIE

Clinical Antipsychotic Trials of Intervention Effectiveness

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 1,493 patients with chronic schizophrenia, olanzapine, quetiapine, risperidone or ziprasidone achieved the same time to discontinuation as perphenazine, with most patients stopping treatment by 18 months.

1 493

Schéma

Multi-phase pragmatic RCT, USA

Critère

Time to all-cause discontinuation

Pertinence

Résultat~74% discontinued within 18 months across arms; olanzapine had the longest time-to-discontinuation but most weight gain.

Lieberman JA, et al. N Engl J Med. 2005;353(12):1209-1223. 10.1056/NEJMoa051688

Discussion et critique

Backdrop for why psychosocial augmentation matters: even with modern antipsychotics, real-world adherence is poor.