CATIE
Clinical Antipsychotic Trials of Intervention Effectiveness
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,493 patients with chronic schizophrenia, olanzapine, quetiapine, risperidone or ziprasidone achieved the same time to discontinuation as perphenazine, with most patients stopping treatment by 18 months.
N
1.493
Design
Multi-phase pragmatic RCT, USA
Endpunkt
Time to all-cause discontinuation
Relevanz
1
Ergebnis~74% discontinued within 18 months across arms; olanzapine had the longest time-to-discontinuation but most weight gain.
Lieberman JA, et al. N Engl J Med. 2005;353(12):1209-1223. 10.1056/NEJMoa051688
Diskussion & Kritik
Backdrop for why psychosocial augmentation matters: even with modern antipsychotics, real-world adherence is poor.