Carroll CBT
CBT and Disulfiram for Cocaine Dependence
Doente / População Intervenção / Exposição Comparação Desfecho
In cocaine-dependent adults (with and without alcohol misuse), CBT-relapse prevention with disulfiram produced larger 12-month abstinence than clinical management or single-modality treatment.
N
121
Desenho
Double-masked placebo-controlled 2×2 factorial RCT (disulfiram vs placebo × CBT vs IPT), 12 wk, USA
Desfecho
Frequency of cocaine use (self-report + urine toxicology)
Relevância
2
ResultadoDisulfiram > placebo (P<.01) and CBT > IPT (P<.01) in reducing cocaine use; benefit largest without baseline alcohol dependence.
Carroll KM, et al. Arch Gen Psychiatry. 2004;61(3):264-272. 10.1001/archpsyc.61.3.264
Discussão e crítica
Showed CBT's effects can grow after treatment ends — important for measuring 'efficacy' too early.