Carroll CBT

CBT and Disulfiram for Cocaine Dependence

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In cocaine-dependent adults (with and without alcohol misuse), CBT-relapse prevention with disulfiram produced larger 12-month abstinence than clinical management or single-modality treatment.

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Disegno

Double-masked placebo-controlled 2×2 factorial RCT (disulfiram vs placebo × CBT vs IPT), 12 wk, USA

Esito

Frequency of cocaine use (self-report + urine toxicology)

Rilevanza

RisultatoDisulfiram > placebo (P<.01) and CBT > IPT (P<.01) in reducing cocaine use; benefit largest without baseline alcohol dependence.

Carroll KM, et al. Arch Gen Psychiatry. 2004;61(3):264-272. 10.1001/archpsyc.61.3.264

Discussione e critica

Showed CBT's effects can grow after treatment ends — important for measuring 'efficacy' too early.