CARE-HF

Cardiac Resynchronisation in Heart Failure

Patient / Population Intervention / Exposure Comparison Outcome

In 813 patients with heart failure and a wide QRS, cardiac resynchronisation therapy reduced death or unplanned cardiovascular hospitalisation compared with medical therapy.

813

Design

RCT

Endpoint

Death or unplanned CV hospitalisation

Relevance

Result39 % vs 55 %; all-cause mortality HR 0.64.

Cleland JGF, et al. N Engl J Med. 2005;352(15):1539-1549. 10.1056/NEJMoa050496

Discussion & critique

Showed a mortality benefit from resynchronisation alone — the evidence base for CRT-P. The CRT-P versus CRT-D question remains individualised.