CALORIES
Early Enteral or Parenteral Nutrition in Critical Illness
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 2,400 critically ill adults, early parenteral nutrition did not change 30-day mortality compared with early enteral nutrition.
N
2400
Disegno
Multicentre RCT, UK
Esito
30-day all-cause mortality
Rilevanza
3
Risultato33.1% (parenteral) vs 34.2% (enteral); RR 0.97 (95% CI 0.86–1.08), p=0.57.
Harvey SE, et al. N Engl J Med. 2014;371(18):1673-1684. 10.1056/NEJMoa1409860
Discussione e critica
Route matters less than once thought, provided initial resuscitation is complete.