BPROAD
Blood Pressure Control Targets in Diabetes
Paciente / Población Intervención / Exposición Comparación Desenlace
In 12,821 patients with type 2 diabetes, intensive blood-pressure control to below 120 mm Hg reduced major cardiovascular events compared with a target below 140 mm Hg.
N
12.821
Diseño
Open-label RCT
Desenlace
Major cardiovascular events
Relevancia
2
ResultadoHR 0.79 (21 % RRR); more hyperkalaemia in the intensive arm.
Bi Y, et al. N Engl J Med. 2025;392(12):1155-1167. 10.1056/NEJMoa2412006
Discusión y crítica
Overturns the neutral ACCORD-BP result and extends the intensive target to diabetes. Chinese cohort; monitoring for AKI and hyperkalaemia is essential.