BOX (BP)
Blood-Pressure Targets after Out-of-Hospital Cardiac Arrest
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 789 comatose survivors of OHCA, a higher MAP target (77 mm Hg) did not change the composite of death or severe disability versus a lower target (63 mm Hg).
N
789
Disegno
Multicentre factorial RCT (BOX), Denmark
Esito
Death from any cause or severe disability/coma at 90 days
Rilevanza
2
Risultato34% vs 32% (HR 1.08; 95% CI 0.84–1.37).
Kjaergaard J, et al. N Engl J Med. 2022;387(16):1456-1466. 10.1056/NEJMoa2208687
Discussione e critica
MAP ≥65 mm Hg suffices; no benefit chasing higher targets.