BaSICS

Balanced Solutions in Intensive Care Study

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 11,052 ICU patients, Plasma-Lyte did not reduce 90-day mortality compared with saline, with possible harm in traumatic brain injury.

11 052

Schéma

Multicentre factorial RCT, Brazil

Critère

90-day all-cause mortality

Pertinence

Résultat26.4% vs 27.2% (HR 0.97; 95% CI 0.90–1.05). Pre-specified TBI subgroup harm with balanced.

Zampieri FG, et al. JAMA. 2021;326(9):818-829. 10.1001/jama.2021.11684

Discussion et critique

Balanced fluids weakly preferred overall but use saline in TBI.