ANGEL-ASPECT
Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 456 Chinese patients with LVO and large ischaemic core, endovascular therapy improved the 90-day mRS distribution versus medical management.
N
456
Disegno
Multicentre RCT, China
Esito
mRS shift at 90 days
Rilevanza
3
RisultatoGeneralised OR 1.37 (95% CI 1.11–1.69; p=0.004); mRS 0–2 30.0% vs 11.6%.
Huo X, et al. N Engl J Med. 2023;388(14):1272-1283. 10.1056/NEJMoa2213379
Discussione e critica
Confirms SELECT2 — large-core trials redefine the lower limit of viable tissue.