ANGEL-ASPECT
Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 456 Chinese patients with LVO and large ischaemic core, endovascular therapy improved the 90-day mRS distribution versus medical management.
N
456
Schéma
Multicentre RCT, China
Critère
mRS shift at 90 days
Pertinence
3
RésultatGeneralised OR 1.37 (95% CI 1.11–1.69; p=0.004); mRS 0–2 30.0% vs 11.6%.
Huo X, et al. N Engl J Med. 2023;388(14):1272-1283. 10.1056/NEJMoa2213379
Discussion et critique
Confirms SELECT2 — large-core trials redefine the lower limit of viable tissue.