ADVENT
Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 607 patients with paroxysmal AF, pulsed-field ablation was non-inferior to conventional thermal ablation for treatment success and safety.
N
607
Design
Randomised, non-inferiority RCT
Endpunkt
Freedom from atrial arrhythmia + safety composite
Relevanz
3
Ergebnis73.3 % vs 71.3 % efficacy; serious adverse events 2.1 % vs 1.5 %.
Reddy VY, et al. N Engl J Med. 2023;389(18):1660-1671. 10.1056/NEJMoa2307291
Diskussion & Kritik
First randomised PFA-versus-thermal trial. Non-inferiority, not superiority — PFA's appeal is tissue selectivity and workflow rather than higher efficacy.