ACURASYS
Neuromuscular Blockers in Early ARDS
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 340 patients with severe ARDS within 48 hours, 48-hour cisatracurium infusion reduced 90-day mortality compared with placebo.
N
340
Disegno
Multicentre RCT, France
Esito
Adjusted 90-day mortality
Rilevanza
3
RisultatoAdjusted HR 0.68 (95% CI 0.48–0.98; p=0.04).
Papazian L, et al. N Engl J Med. 2010;363(12):1107-1116. 10.1056/NEJMoa1005372
Discussione e critica
Mortality benefit not replicated in ROSE; routine NMB no longer recommended in modern, lightly sedated ARDS.