ABC
Awakening and Breathing Controlled Trial
Doente / População Intervenção / Exposição Comparação Desfecho
In 336 mechanically ventilated ICU patients, a daily spontaneous-awakening + breathing trial increased ventilator-free days versus breathing trials alone, and reduced 1-year mortality.
N
336
Desenho
Multicentre RCT, USA
Desfecho
Ventilator-free days at 28 days
Relevância
1
Resultado14.7 vs 11.6 (Δ 3.1; p=0.02); shorter ICU LOS; 1-y mortality 44% vs 58% (HR 0.68; p=0.01).
Girard TD, et al. Lancet. 2008;371(9607):126-134. 10.1016/S0140-6736(08)60105-1
Discussão e crítica
Cornerstone of the ABCDEF bundle; daily SATs save lives.