AASK
African American Study of Kidney Disease and Hypertension
Doente / População Intervenção / Exposição Comparação Desfecho
In 1,094 Black patients with hypertensive nephrosclerosis, ramipril slowed kidney-disease progression compared with amlodipine or metoprolol.
N
1094
Desenho
3×2 factorial RCT
Desfecho
Composite of GFR decline, ESRD or death
Relevância
2
ResultadoRamipril vs amlodipine 38% risk reduction in clinical composite (95% CI 14–56%, p=0.004).
Wright JT, et al. JAMA. 2002;288(19):2421-2431. 10.1001/jama.288.19.2421
Discussão e crítica
The only major CKD trial conducted entirely in a Black population; informed the later blood-pressure-target debate.