AASK
African American Study of Kidney Disease and Hypertension
Patient / Population Intervention / Exposure Comparison Outcome
In 1,094 Black patients with hypertensive nephrosclerosis, ramipril slowed kidney-disease progression compared with amlodipine or metoprolol.
N
1,094
Design
3×2 factorial RCT
Endpoint
Composite of GFR decline, ESRD or death
Relevance
2
ResultRamipril vs amlodipine 38% risk reduction in clinical composite (95% CI 14–56%, p=0.004).
Wright JT, et al. JAMA. 2002;288(19):2421-2431. 10.1001/jama.288.19.2421
Discussion & critique
The only major CKD trial conducted entirely in a Black population; informed the later blood-pressure-target debate.