6S
Scandinavian Starch for Severe Sepsis/Septic Shock
Patient / Population Intervention / Exposure Comparison Outcome
In 804 patients with severe sepsis, 6% HES 130/0.42 increased 90-day death or dialysis versus Ringer's acetate.
N
804
Design
Multicentre RCT, Scandinavia
Endpoint
90-day death or dialysis dependence
Relevance
2
Result51% vs 43% (RR 1.17; 95% CI 1.01–1.36; p=0.03).
Perner A, et al. N Engl J Med. 2012;367(2):124-134. 10.1056/NEJMoa1204242
Discussion & critique
Direct kidney-harm signal; co-decisive with CHEST in the EMA HES restriction.