Webster Cabergoline Trial
Cabergoline versus Bromocriptine in Hyperprolactinaemic Amenorrhoea
Doente / População Intervenção / Exposição Comparação Desfecho
In 459 women with hyperprolactinaemic amenorrhoea, cabergoline 0.5–1.0 mg twice weekly achieved stable normoprolactinaemia, ovulation and pregnancy more often than bromocriptine.
N
459
Desenho
Double-blind RCT
Desfecho
Stable normoprolactinaemia
Relevância
3
ResultadoNormoprolactinaemia 83 % vs 59 % (p<0.001); ovulation/pregnancy 72 % vs 52 %; better tolerability.
Webster J, et al. N Engl J Med. 1994;331(14):904-909. 10.1056/NEJM199410063311403
Discussão e crítica
Established cabergoline as first-line therapy for prolactinoma — a position unchanged for three decades.