VITAMINS
Vitamin C, Thiamine and Steroids in Sepsis
Patient / Population Intervention / Exposure Comparison Outcome
In 216 patients with septic shock, hydrocortisone + vitamin C + thiamine did not increase vasopressor-free time versus hydrocortisone alone.
N
216
Design
Open-label RCT
Endpoint
Time alive and vasopressor-free to day 7
Relevance
3
Result122.1 vs 124.6 h (p=0.83); no mortality difference.
Fujii T, et al. JAMA. 2020;323(5):423-431. 10.1001/jama.2019.22176
Discussion & critique
Closed the door on the metabolic-cocktail hypothesis alongside LOVIT and CITRIS-ALI.