VICTAS
Vitamin C, Thiamine and Steroids in Sepsis
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 501 patients with sepsis-induced respiratory or cardiovascular failure, vitamin C + thiamine + hydrocortisone did not increase ventilator- and vasopressor-free days versus placebo.
N
501
Disegno
Multicentre RCT, terminated early for funding
Esito
Ventilator- and vasopressor-free days through day 30
Rilevanza
3
RisultatoMedian 25 vs 26 (p=0.85); 30-d mortality 22% vs 24%.
Sevransky JE, et al. JAMA. 2021;325(8):742-750. 10.1001/jama.2020.24505
Discussione e critica
Stopped early but consistent with VITAMINS and LOVIT — no benefit of the cocktail.