VICTAS
Vitamin C, Thiamine and Steroids in Sepsis
Patient / Population Intervention / Exposure Comparison Outcome
In 501 patients with sepsis-induced respiratory or cardiovascular failure, vitamin C + thiamine + hydrocortisone did not increase ventilator- and vasopressor-free days versus placebo.
N
501
Design
Multicentre RCT, terminated early for funding
Endpoint
Ventilator- and vasopressor-free days through day 30
Relevance
3
ResultMedian 25 vs 26 (p=0.85); 30-d mortality 22% vs 24%.
Sevransky JE, et al. JAMA. 2021;325(8):742-750. 10.1001/jama.2020.24505
Discussion & critique
Stopped early but consistent with VITAMINS and LOVIT — no benefit of the cocktail.