VASST
Vasopressin and Septic Shock Trial
Doente / População Intervenção / Exposição Comparação Desfecho
In 778 patients with septic shock on ≥5 µg/min norepinephrine, low-dose vasopressin added to norepinephrine did not reduce 28-day mortality compared with norepinephrine alone.
N
778
Desenho
Double-blind RCT
Desfecho
28-day all-cause mortality
Relevância
2
Resultado35.4% vs 39.3% (p=0.26). Less-severe subgroup 26.5% vs 35.7% (p=0.05; hypothesis-generating).
Russell JA, et al. N Engl J Med. 2008;358(9):877-887. 10.1056/NEJMoa067373
Discussão e crítica
Vasopressin is a safe catecholamine-sparing adjunct; routine in most modern septic-shock protocols.