VASST
Vasopressin and Septic Shock Trial
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 778 patients with septic shock on ≥5 µg/min norepinephrine, low-dose vasopressin added to norepinephrine did not reduce 28-day mortality compared with norepinephrine alone.
N
778
Disegno
Double-blind RCT
Esito
28-day all-cause mortality
Rilevanza
2
Risultato35.4% vs 39.3% (p=0.26). Less-severe subgroup 26.5% vs 35.7% (p=0.05; hypothesis-generating).
Russell JA, et al. N Engl J Med. 2008;358(9):877-887. 10.1056/NEJMoa067373
Discussione e critica
Vasopressin is a safe catecholamine-sparing adjunct; routine in most modern septic-shock protocols.